Two sample MR report
HLA-DQA2_T Proliferating against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 30 | -0.0042449 | 0.0219538 | 0.8480779 |
| Weighted median | 30 | 0.0137474 | 0.0040373 | 0.0006613 |
| Inverse variance weighted | 30 | 0.0105205 | 0.0027809 | 0.0001548 |
| Simple mode | 30 | 0.0165721 | 0.0083348 | 0.0562915 |
| Weighted mode | 30 | 0.0163867 | 0.0080329 | 0.0505558 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 25.20507 | 28 | 0.6166519 |
| Inverse variance weighted | 25.66479 | 29 | 0.6433421 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0130838 | 0.0192969 | 0.503321 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004913 | 0 | TRUE | 0.0361928 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
